改良されたＮＯＧＯ−Ａ結合分子およびその医薬的使用

Title:

改良されたＮＯＧＯ−Ａ結合分子およびその医薬的使用

Document Type and Number:

Japanese Patent JP5698534

Kind Code:

B2

Abstract:

The present invention provides a binding molecule which is capable of binding to the human NogoA polypeptide or human NiG with a dissociation constant <1000 nM, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment of a disease of the peripheral (PNS) and/or central (CNS) nervous system; a pharmaceutical composition comprising said binding molecule; and a method of treatment of a disease of the peripheral (PNS) and/or central (CNS) nervous system.

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Inventors:

Carmen Barsuke
Stephan Frenzel
Anise Curso Mar
Martin A Schwab
Alessandra Vitality

Application Number:

JP2010531504A

Publication Date:

April 08, 2015

Filing Date:

October 27, 2008

Export Citation:

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Assignee:

Novartis Age

International Classes:

C12N15/09; A61K39/395; A61K48/00; A61P25/00; C07K16/28; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08; A61K39/00

Domestic Patent References:

JP2007527232A
JP2006523087A

Attorney, Agent or Firm:

Hiroshi Kobayashi
Norio Omori
Yasuhito Suzuki

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