Title:
ＭＵＣ１のアンタゴニストを使用した、炎症の阻害
Document Type and Number:
Japanese Patent JP5702371
Kind Code:
B2
Abstract:
The invention provides for peptides from the MUC1 cytoplasmic domain and methods of use therefor. These peptides can inhibit MUC1 oligomerization, inhibit the interaction of MUC1 with NF-κB or a STAT, and block inflammatory response mediated by NF-κB or STAT signaling.
Inventors:
Coupe Donald W.
Calvanda Slender
Calvanda Slender
Application Number:
JP2012513262A
Publication Date:
April 15, 2015
Filing Date:
May 27, 2010
Export Citation:
Assignee:
Dana Faber Cancer Institute, Incorporated
Genus Oncology Limited Liability Company
Genus Oncology Limited Liability Company
International Classes:
A61K38/00; A61K31/56; A61P29/00; A61P43/00; C07K7/06; C07K7/08
Domestic Patent References:
| JP2008536873A | ||||
| JP2008537095A | ||||
| JP2003510094A | ||||
| JP2002531583A |
Foreign References:
| US5912232 | ||||
| US20020044943 |
Other References:
Clinical Cancer Research,2009年 1月,Vol.15,No.1,p100-109
Journal of Biological Chemistry,2007年,Vo.282,No.27,p19321-19330
Nature Cell Biology,2007年,Vol.9,No.12,p1419-1427
Journal of Biological Chemistry,2007年,Vo.282,No.27,p19321-19330
Nature Cell Biology,2007年,Vol.9,No.12,p1419-1427
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto