インフルエンザＢウイルス変異体およびその使用

Title:

インフルエンザＢウイルス変異体およびその使用

Document Type and Number:

Japanese Patent JP7280832

Kind Code:

B2

Abstract:

Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant BM2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.

Inventors:

Moser Michael Jay
Yasuko Hatta
Birsel Pamuk

Application Number:

JP2019546929A

Publication Date:

May 24, 2023

Filing Date:

February 26, 2018

Export Citation:

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Assignee:

Fulgen Inc.

International Classes:

C12N7/01; A61K39/145; A61K39/39; A61P31/16

Domestic Patent References:

JP2011505863A

Foreign References:

WO2015142671A2

Other References:

Cytoplasmic Domain of Influenza B Virus BM2 Protein Plays Critical Roles in Production of Infectious Virus,Journal of Virology,2008年,Volume 82, Number 2,pp. 728-739
Database GenBank [online],Accession No.CY033877.1, 21 Jul 2008, [検索日 2022.9.16]
Influenza B Virus BM2 Protein Is a Crucial Component for Incorporation of Viral Ribonucleoprotein Complex into Virions during Virus Assembly,Journal of Virology,2004年,Vol. 78, No. 20,p. 11007-11015
Influenza A Virus Lacking M2 Protein as a Live Attenuated Vaccine,Journal of Virology,2009年,Volume 83, Number 11,pp. 5947-5950

Attorney, Agent or Firm:

Shinichiro Tanaka
▲吉▼田和彦
Hiroyuki Suda
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Gen Tashiro

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