Title:
Integrin joint kinase inhibitor
Document Type and Number:
Japanese Patent JP5986098
Kind Code:
B2
Abstract:
A number of compounds and use of the compounds in a method for treating or preventing cancer in a subject by administering to the subject a pharmaceutical composition including a compound of formula I or a pharmaceutically acceptable salt thereof are described. The compounds can also be used to inhibit integrin-linked kinase in a cell, which has an effect on the Akt signaling pathway.
Inventors:
Chen, Chin-Chi
Lee, Soo Lin
Calpe, Samuel K.
Lee, Soo Lin
Calpe, Samuel K.
Application Number:
JP2013540988A
Publication Date:
September 06, 2016
Filing Date:
November 21, 2011
Export Citation:
Assignee:
The Ohio State University Research Foundation
International Classes:
C07D231/12; A61K31/415; A61K31/496; A61P35/00; A61P35/02; A61P43/00; C07D231/14
Foreign References:
| US20080146815 | ||||
| US20090111799 | ||||
| US6750239 |
Other References:
Lee, Su-Lin; Hsu, En-Chi; Chou, Chih-Chien; Chuang, Hsiao-Ching; Bai, Li-Yuan; Kulp, Samuel K.; Chen, Ching-Shih,Identification and Characterization of a Novel Integrin-Linked Kinase Inhibitor,Journal of Medicinal Chemistry ,2011年,Vol. 54, Iss. 18,P. 6364-6374,Publish Online 2011.8.8
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto