Title:
改良された安定性を有するインターロイキン-12P40変種
Document Type and Number:
Japanese Patent JP5175214
Kind Code:
B2
Abstract:
Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.
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Inventors:
Webster Gordon Dee
Mackenzie Suzanne Pea
Rokin Min
Stein Pascal Andre
Mackenzie Suzanne Pea
Rokin Min
Stein Pascal Andre
Application Number:
JP2008547880A
Publication Date:
April 03, 2013
Filing Date:
December 20, 2006
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
C12N15/09; A61K38/00; A61P35/00; A61P37/02; C07K14/54; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Domestic Patent References:
| JP2001161378A | ||||
| JP2003517305A | ||||
| JP2002167400A |
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Toshio Takizawa
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Toshio Takizawa