Title:
インターロイキン−２／インターロイキン−２受容体アルファ融合タンパク質および使用方法
Document Type and Number:
Japanese Patent JP6723982
Kind Code:
B2
Abstract:
Various methods and compositions are provided which can be employed to modulate the immune system. Compositions include a fusion protein comprising: (a) a first polypeptide comprising Interleukin-2 (IL-2) or a functional variant or fragment thereof; and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL-2Rα) or a functional variant or fragment thereof, and wherein the fusion protein has IL-2 activity. Various methods are provided for modulating the immune response in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the IL-2/IL-2Rα fusion protein disclosed herein.
Inventors:
Thomas Marek
Application Number:
JP2017506395A
Publication Date:
July 15, 2020
Filing Date:
August 05, 2015
Export Citation:
Assignee:
UNIVERSITY OF MIAMI
International Classes:
C07K19/00; A61K38/20; A61K47/65; A61P1/04; A61P9/00; A61P17/06; A61P17/14; A61P19/02; A61P29/00; A61P37/02; C07K14/55; C07K14/715; C12N5/10; C12N15/26; C12N15/63; C12P21/02
Domestic Patent References:
| JP10511846A | ||||
| JP2008545397A |
Foreign References:
| WO2010020766A1 | ||||
| WO2003029475A1 | ||||
| US20130089516 |
Other References:
Nature Med., 2007年,Vol.13, No.9,p.1108-1113
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Hiroshi Yamazaki
Kenji Tomita