Title:
ヨウ素化X線コントラスト媒体
Document Type and Number:
Japanese Patent JP3591840
Kind Code:
B2
Abstract:
The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula I (I) (wherein n is 0 or 1, and where n is 1 each C6R5 moeity may be the same or different; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M1, two or three non-adjacent R groups in each C6R5 moiety being iodine and at least one, and preferably two or three, R groups in each C6R5 moiety being M or M1 moieties; X denotes a bond or a group providing a 1 to 7 atom chain linking two C6R5 moieties or, where n is 0, X denotes a group R; each M independently is a non-ionic hydrophilic moiety; and each M1 independently represents a C1-4alkyl group substituted by at least one hydroxyl group and optionally linked to the phenyl ring via a carbonyl, sulphone or sulphoxide group, at least one R group being an M1 moiety; with the proviso that where n is zero either at least one M1 group other than a hydroxymethyl or 1,2-dihydroxyethyl group is present or then if one hydroxymethyl or 1,2-dihydroxyethyl M1 group is present at least one nitrogen-attached or hydroxylated-C3-4 alkyl moiety-containing M group is also present) and isomers thereof.
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Inventors:
Almen, Torsten
Anderson, Sven
Wystrand, Lars-Golan
Gorman, Claes
Antonsen, Wivind
Fosheim, Rene
Vigen, Uni, Noordby
Victor, hakan
Clingstedt, Thomas
Ein Roinbach
Berg, Arne
Doug Stud, Harald
Anderson, Sven
Wystrand, Lars-Golan
Gorman, Claes
Antonsen, Wivind
Fosheim, Rene
Vigen, Uni, Noordby
Victor, hakan
Clingstedt, Thomas
Ein Roinbach
Berg, Arne
Doug Stud, Harald
Application Number:
JP51070696A
Publication Date:
November 24, 2004
Filing Date:
September 22, 1995
Export Citation:
Assignee:
Amersham Health Aksuye Sersukapu
International Classes:
A61K49/04; C07C33/46; C07C33/48; C07C43/295; C07C49/83; C07C69/02; C07C69/12; C07C233/43; C07C235/16; C07C237/46; C07C275/42; C07C307/10; C07C311/29; C07C317/22; (IPC1-7): C07C33/46; A61K49/04; C07C33/48; C07C43/295; C07C49/83; C07C69/02; C07C69/12; C07C233/43; C07C235/16; C07C237/46; C07C275/42; C07C307/10; C07C311/29; C07C317/22
Domestic Patent References:
| JP10505856A | ||||
| JP6228066A | ||||
| JP5208921A |
Foreign References:
| US5348727 | ||||
| WO1994014478A1 | ||||
| WO1993016375A1 | ||||
| WO1993010078A1 | ||||
| WO1993012071A1 | ||||
| WO1993010825A1 | ||||
| DE2317535A |
Other References:
INVESTIGATIVE RADIOLOGY, 1994年 6月,Volume 29,Supplement 2, S275-S277
Attorney, Agent or Firm:
Shunichiro Suzuki