Title:
キナーゼネットワークの阻害剤およびその使用
Document Type and Number:
Japanese Patent JP2020523282
Kind Code:
A
Abstract:
本発明は、一般に、炎症、癌、ウイルスおよび細菌感染、神経障害および免疫障害などの、キナーゼおよび／またはヒストンデメチラーゼによって媒介される疾患の治療に有用な二重キナーゼ−デメチラーゼ阻害剤としての化合物に関する。これらの疾患を治療するための医薬組成物および方法は、本発明の範囲内である。
Inventors:
Shintim, Herman Oh.
Dayal, Netu
Opoku-Temen, Clement
Dayal, Netu
Opoku-Temen, Clement
Application Number:
JP2019552978A
Publication Date:
August 06, 2020
Filing Date:
March 29, 2018
Export Citation:
Assignee:
Purdue Research Foundation
International Classes:
C07D471/04; A61K9/14; A61K31/4745; A61K31/496; A61K31/506; A61K31/519; A61K31/5377; A61K31/69; A61K38/53; A61P1/04; A61P9/00; A61P25/00; A61P27/02; A61P29/00; A61P31/04; A61P31/12; A61P35/00; A61P37/02; A61P43/00; C07D471/14; C07D491/048; C07D491/147; C07D495/04; C07D495/14; C07D498/04; C07D513/04; C07D519/00
Domestic Patent References:
| JP2002542193A | 2002-12-10 | |||
| JP2013542243A | 2013-11-21 | |||
| JPS61210085A | 1986-09-18 | |||
| JP2022081529A | 2022-05-31 | |||
| JP2006524634A | 2006-11-02 | |||
| JP2002531523A | 2002-09-24 | |||
| JP2008545785A | 2008-12-18 |
Foreign References:
| WO2011043359A1 | 2011-04-14 | |||
| WO2016112284A1 | 2016-07-14 | |||
| US20050080260A1 | 2005-04-14 |
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BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22(17), JPN6022025007, 2014, pages 4704 - 4710, ISSN: 0004979469
FREY, JULIEN 他: "Synthesis of a bis-macrocycle containing two back-to-back rigidly connected 1,10-phenanthroline unit", CHEMISTRY - A EUROPEAN JOURNAL, vol. 13(27),, JPN6021047166, 2007, pages 7584 - 7594, ISSN: 0004979465
WANG, WEI 他: "Iodine-Catalyzed Synthesis of Cyclopenta[c]quinoline Derivatives via Imino Diels-Alder Reaction", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 51(3),, JPN6021047165, 2014, pages 830 - 834, ISSN: 0004979466
ZHANG, WEN-TING 他: "Iodine-Catalyzed Synthesis of Fused Polycyclic Heterocycles Containing Pyrazoloquinoline via Povarov", POLYCYCLIC AROMATIC COMPOUNDS, vol. 36(4),, JPN6021047164, 2016, pages 275 - 283, ISSN: 0004979467
FERLIN, MARIA GRAZIA 他: "Design, Synthesis, and Structure-Activity Relationships of Azolylmethylpyrroloquinolines as Nonstero", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56(19),, JPN6021047163, 2013, pages 7536 - 7551, ISSN: 0004979468
RASHA M. ALY 他: "Quinoline-based small molecules as effective protein kinases inhibitors (Review)", JOURNAL OF AMERICAN SCIENCE, vol. 12(5),, JPN7021005151, 2016, pages 10 - 32, ISSN: 0004979461
CHOU, LI-CHEN 他: "Design, Synthesis, and Preclinical Evaluation of New 5,6- (or 6,7-) Disubstituted-2-(fluorophenyl)qu", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53(22),, JPN6021047171, 2010, pages 8047 - 8058, ISSN: 0004979462
FERLIN, MARIA GRAZIA 他: "New water soluble pyrroloquinoline derivatives as new potential anticancer agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13(15), JPN6021047169, 2005, pages 4733 - 4739, ISSN: 0004979463
FERLIN, MARIA GRAZIA 他: "DNA binding ellipticine analogues: synthesis, biological evaluation, and structure-activity relation", CHEMMEDCHEM, vol. 4(3),, JPN6021047168, 2009, pages 363 - 377, ISSN: 0004979464
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22(17), JPN6022025007, 2014, pages 4704 - 4710, ISSN: 0004979469
Attorney, Agent or Firm:
Asamura patent office