Title:
KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
Document Type and Number:
Japanese Patent JP2017081918
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide kynurenine-3-monooxygenase inhibitors, and pharmaceutical compositions thereof.SOLUTION: The present invention provides a compound represented by formula (I) and pharmaceutically acceptable salt and prodrugs (X and Y are N or CH (one of them is N); Ris aryl or heteroaryl; Ris H or substituted/unsubstituted lower alkyl; Ris H, substituted/unsubstituted lower alkyl or the like. L is carbonyl, amide or the like; Ris H, substituted/unsubstituted lower alkyl, substituted/unsubstituted aryl or the like).SELECTED DRAWING: None
Inventors:
STEPHEN MARTIN COURTNEY
MICHAEL PRIME
WILLIAM MITCHELL
CHRISTOPHER JOHN BROWN
PAULA C DE AGUIAR PENA
PETER JOHNSON
CELIA DOMINGUEZ
LETICIA M TOLEDO-SHERMAN
IGNACIO MUNOZ
MICHAEL PRIME
WILLIAM MITCHELL
CHRISTOPHER JOHN BROWN
PAULA C DE AGUIAR PENA
PETER JOHNSON
CELIA DOMINGUEZ
LETICIA M TOLEDO-SHERMAN
IGNACIO MUNOZ
Application Number:
JP2016214165A
Publication Date:
May 18, 2017
Filing Date:
November 01, 2016
Export Citation:
Assignee:
CHDI FOUNDATION INC
International Classes:
C07D213/79; A61K31/4418; A61K31/505; A61K31/506; A61K31/519; A61K31/5377; A61K31/7064; A61P25/14; A61P25/28; A61P43/00; C07D239/28; C07D239/42; C07D239/69; C07D401/04; C07D401/12; C07D403/04; C07D403/12; C07D405/04; C07D405/12; C07D405/14; C07D413/04; C07D491/048; C07D491/052; C07H15/26
Other References:
THE FEBS JOURNAL, vol. Vol.279, JPN6017036644, April 2012 (2012-04-01), pages 1386 - 1397
ARCH. GEN. PSYCHIATRY., vol. Vol.68(7), JPN6017036645, 2011
J. MED. CHEM., vol. Vol.58, JPN6017036647, 2015, pages 8762 - 8782
THE FEBS JOURNAL, vol. Vol.279, JPN6017036644, April 2012 (2012-04-01), pages 1386 - 1397
ARCH. GEN. PSYCHIATRY., vol. Vol.68(7), JPN6017036645, 2011
J. MED. CHEM., vol. Vol.58, JPN6017036647, 2015, pages 8762 - 8782
A.C.N.R., vol. Vol.12(1), JPN6017036649, April 2012 (2012-04-01), pages 7 - 8
A.C.N.R., vol. Vol.12(1), JPN6017036649, April 2012 (2012-04-01), pages 7 - 8
ARCH. GEN. PSYCHIATRY., vol. Vol.68(7), JPN6017036645, 2011
J. MED. CHEM., vol. Vol.58, JPN6017036647, 2015, pages 8762 - 8782
THE FEBS JOURNAL, vol. Vol.279, JPN6017036644, April 2012 (2012-04-01), pages 1386 - 1397
ARCH. GEN. PSYCHIATRY., vol. Vol.68(7), JPN6017036645, 2011
J. MED. CHEM., vol. Vol.58, JPN6017036647, 2015, pages 8762 - 8782
A.C.N.R., vol. Vol.12(1), JPN6017036649, April 2012 (2012-04-01), pages 7 - 8
A.C.N.R., vol. Vol.12(1), JPN6017036649, April 2012 (2012-04-01), pages 7 - 8
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta