Title:
治療剤の改良された細胞内送達のためのリポソーム組成物
Document Type and Number:
Japanese Patent JP2004525138
Kind Code:
A
Abstract:
A liposomal composition and a method of using the same for achieving intracellular delivery of a liposome-entrapped agent is described. The liposomes are composed of a pH sensitive lipid and include a targeting ligand to direct the liposomes to a target cell. The liposomes also include a stabilizing component, such a polymer-derivatized lipid, where the polymer is attached to the lipid by a releasable linkage. Administration of the liposomes results in cellular internalization and destabilization of the liposome for intracellular delivery of the entrapped agent.
Inventors:
The Lipskiy, Samuel
Allen, Teresa M
Hiyun, Shi Ku
Allen, Teresa M
Hiyun, Shi Ku
Application Number:
JP2002574944A
Publication Date:
August 19, 2004
Filing Date:
March 26, 2002
Export Citation:
Assignee:
Alza Corporation
International Classes:
A61K9/127; A61K9/133; A61K9/54; A61K39/395; A61K47/24; A61K47/28; A61K47/30; A61K47/34; A61K47/46; A61K47/48; (IPC1-7): A61K9/127; A61K39/395; A61K47/24; A61K47/28; A61K47/30; A61K47/34; A61K47/46
Attorney, Agent or Firm:
Heikichi Odashima
Previous Patent: ケラチン繊維の強化および構造改善に対するクレアチン、クレアチニンお...
Next Patent: ＦＬＴ−１リガンド、および血管形成により調節可能な疾患の治療におけ...
Next Patent: ＦＬＴ−１リガンド、および血管形成により調節可能な疾患の治療におけ...