Title:
LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS
Document Type and Number:
Japanese Patent JP2015155418
Kind Code:
A
Abstract:
【課題】甲状腺ガンの検出若しくは治療、または骨変性障害の治療に用いることができる選択的な甲状腺刺激ホルモン受容体（TSHR）アゴニストとして有用なオキソヒドロキナゾリン類の提供。【解決手段】下式で表される化合物。［R1-R4は各々独立にH、ヒドロキシル等;R5は−ＣＨ２−Ｐｈ;Aは-N=C(R15)-（左端の結合手が上記式のベンゼン環に結合し、右端の結合手が上記式のヘテロ原子窒素に結合する）等、R15は特定の置換基を有するフェニル］【選択図】なし
Inventors:
MARVIN C GERSHENGORN
SUSANNE NEUMANN
BRUCE M RAAKA
CRAIG J THOMAS
JAMES INGLESE
NOEL T SOUTHALL
STEVEN TITUS
ZHENG WEI
HUANG WEN-WEI
GERD KRAUSE
GUNNAR KLEINAU
SUSANNE NEUMANN
BRUCE M RAAKA
CRAIG J THOMAS
JAMES INGLESE
NOEL T SOUTHALL
STEVEN TITUS
ZHENG WEI
HUANG WEN-WEI
GERD KRAUSE
GUNNAR KLEINAU
Application Number:
JP2015054373A
Publication Date:
August 27, 2015
Filing Date:
March 18, 2015
Export Citation:
Assignee:
GOVERNMENT OF THE US SECRETARY OF THE DEPT OF HEALTH & HUMAN SERVICES
International Classes:
C07D239/91; A61K31/517; A61K33/18; A61K51/00; A61P5/14; A61P19/08; A61P35/00; A61P43/00; C07C233/25; C07C233/60; C07C233/73; C07C235/08; C07C235/48; C07C237/32; C07C237/42; C07C255/57; C07C275/32; C07C311/17; C07D405/06
Domestic Patent References:
| JP2009534364A | 2009-09-24 | |||
| JP2009532450A | 2009-09-10 | |||
| JP2008511600A | 2008-04-17 | |||
| JP2004529918A | 2004-09-30 | |||
| JP2007509118A | 2007-04-12 | |||
| JP2010530736A | 2010-09-16 | |||
| JP2009534364A | 2009-09-24 | |||
| JP2009532450A | 2009-09-10 | |||
| JP2008511600A | 2008-04-17 | |||
| JP2004529918A | 2004-09-30 | |||
| JP2007509118A | 2007-04-12 | |||
| JP2010530736A | 2010-09-16 |
Foreign References:
| WO2008044688A1 | 2008-04-17 | |||
| WO2008044688A1 | 2008-04-17 |
Attorney, Agent or Firm:
Kenji Sugimura