Title:
リンパ管新生促進因子発現線維芽細胞及びそれを含む医薬組成物
Document Type and Number:
Japanese Patent JP7233147
Kind Code:
B2
Abstract:
A fibroblast highly expressing ADM and/or HHEX has been found as a cell having lymphangiogenesis ability, and a procedure for treating fibrosis, a procedure for ameliorating a condition of lymphangiogenesis ability reduced, and procedures for modulating homeostasis of a tissue fluid, transport of lipid and/or vitamin, and immunological surveillance, and for treating organ failure, by use of a pharmaceutical composition including the fibroblast, have been found. In addition, it has been found that an adult-derived fibroblast highly expressing ADM and increasing expression of VCAM-1 is obtained by culturing a human fibroblast with a medium to which TNF-α and IL-4 are added and it has been found that a fibroblast highly expressing ADM is provided, and a procedure for treating a pulmonary disease by use of the fibroblast has been found.
Inventors:
Takahiro Iwamiya
Application Number:
JP2022539639A
Publication Date:
March 06, 2023
Filing Date:
March 03, 2022
Export Citation:
Assignee:
Methusela Co., Ltd.
International Classes:
A61K35/33; A61P3/00; A61P7/00; A61P7/10; A61P11/00; A61P37/06; A61P43/00
Foreign References:
| WO2020045547A1 |
Other References:
KACH, J. et al.,Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedull,Am. J. Physiol. Lung Cell Mol. Physiol.,2013年,304 (11),L757-764
KONG, F. et al.,Exosomal adrenomedullin derived from cancer-associated fibroblasts promotes lipolysis in adipose tis,Gut,2018年,67 (12),pp.2226-2227
DUNWORTH ,W. P. et al.,Adrenomedullin stabilizes the lymphatic endothelial barrier in vitro and in vivo.,Peptides,2008年,29,pp.2243-2249
KONG, F. et al.,Exosomal adrenomedullin derived from cancer-associated fibroblasts promotes lipolysis in adipose tis,Gut,2018年,67 (12),pp.2226-2227
DUNWORTH ,W. P. et al.,Adrenomedullin stabilizes the lymphatic endothelial barrier in vitro and in vivo.,Peptides,2008年,29,pp.2243-2249
Attorney, Agent or Firm:
Patent Attorney Corporation Shuwa Patent Office