Title:
ＭＵＣ１－Ｃ／細胞外ドメイン（ＭＵＣ１－Ｃ／ＥＣＤ）に対する多重特異性抗体構築物
Document Type and Number:
Japanese Patent JP2024522116
Kind Code:
A
Abstract:
本開示は、MUC1-C/細胞外ドメイン（MUC1-C/ECD）と、CD3（分化抗原群3）を含む少なくとも1つの他の結合標的とに結合する多重特異性抗体構築物に関する。そのような構築物を用いて、MUC1抗原を発現するがんを処置する方法も提供する。組換え多重特異性抗体の配列をさらに開示する。
Inventors:
Karbandar Surrender
Panchamoorthy Govindaswamy
Keefe Donald W.
Panchamoorthy Govindaswamy
Keefe Donald W.
Application Number:
JP2023573353A
Publication Date:
June 11, 2024
Filing Date:
May 27, 2022
Export Citation:
Assignee:
XYOne Therapeutics, Inc.
Dana Farber Cancer Institute, Incorporated
Dana Farber Cancer Institute, Incorporated
International Classes:
C07K16/46; A61K9/127; A61K9/51; A61K38/02; A61K38/19; A61K38/43; A61K39/00; A61K39/395; A61K41/00; A61K45/00; A61K47/65; A61K47/68; A61K47/69; A61K49/00; A61K51/10; A61P35/00; A61P35/02; A61P35/04; A61P43/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Attorney, Agent or Firm:
Hatsushi Shimizu
Hideki Kodera
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Kousuke Umemura
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Maki Shioda
Kazuya Kawamoto
Naoko Sakai
Edamatsu Yoshie
Hideki Kodera
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Kousuke Umemura
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Maki Shioda
Kazuya Kawamoto
Naoko Sakai
Edamatsu Yoshie
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