Title:
ピコリナート基を有する大環状配位子、その錯体、及びその医学的使用
Document Type and Number:
Japanese Patent JP6813151
Kind Code:
B2
Abstract:
The present invention relates to compounds, ligands, and/or complexes that are useful in medical imaging and/or in therapy, especially in cancer treatment. The present invention also relates to a pharmaceutical composition comprising said compounds, ligands, and/or complexes that are useful for medical imaging, targeting, and/or treatment of cancers. The present invention also relates to a process for preparing these compounds, ligands, and/or complexes.
Inventors:
Le Full, Marian
Tripie, Raphael
Rousseau, Olivier
Baylor, Marilyn
Tripie, Raphael
Rousseau, Olivier
Baylor, Marilyn
Application Number:
JP2018552912A
Publication Date:
January 13, 2021
Filing Date:
December 23, 2016
Export Citation:
Assignee:
GUERBET
International Classes:
C07D471/08; A61K9/08; A61K31/439; A61K47/14; A61K49/00; A61P1/16; A61P35/00; C07D471/18; C07F5/00
Domestic Patent References:
| JP4506955A |
Foreign References:
| US20090202435 | ||||
| WO2014195416A1 |
Other References:
AIME, S. et al.,NMR relaxometric studies of Gd(III) complexes with heptadentate macrocyclic ligands,Magnetic Resonance in Chemistry,1998年,36,pp. S200-S208
AIME, S. et al.,Designing Novel Contrast Agents for Magnetic Resonance Imaging. Synthesis and Relaxometric Characterization of three Gadolinium(III) Complexes Based on Functionalized Pyridine-Containing Macrocyclic Ligands,Helvetica Chimica Act,2003年,86,pp. 615-632
REGUEIRO-FIGUEROA, M. et al.,Highly Stable Complexes of Divalent Metal Ions (Mg2+, Ca2+, Cu2+, Zn2+, Cd2+, and Pb2+) with a Dota-Like Ligand Containing a Picolinate Pendant,European Journal of Inorganic Chemistry,2014年,2014(36),pp. 6165-6173
REGUEIRO-FIGUEROA, M. et al.,Lanthanide dota-like Complexes Containing a Picolinate Pendant: Structural Entry for the Design of LnIII-Based Luminescent Probes,Inorganic Chemistry,2011年,50(9),pp. 4125-4141
AIME, S. et al.,Designing Novel Contrast Agents for Magnetic Resonance Imaging. Synthesis and Relaxometric Characterization of three Gadolinium(III) Complexes Based on Functionalized Pyridine-Containing Macrocyclic Ligands,Helvetica Chimica Act,2003年,86,pp. 615-632
REGUEIRO-FIGUEROA, M. et al.,Highly Stable Complexes of Divalent Metal Ions (Mg2+, Ca2+, Cu2+, Zn2+, Cd2+, and Pb2+) with a Dota-Like Ligand Containing a Picolinate Pendant,European Journal of Inorganic Chemistry,2014年,2014(36),pp. 6165-6173
REGUEIRO-FIGUEROA, M. et al.,Lanthanide dota-like Complexes Containing a Picolinate Pendant: Structural Entry for the Design of LnIII-Based Luminescent Probes,Inorganic Chemistry,2011年,50(9),pp. 4125-4141
Attorney, Agent or Firm:
Michiharu Soga
Kajinami order
Kazuhiro Oyaku
Saori Sato
Kajinami order
Kazuhiro Oyaku
Saori Sato