Title:
代謝調節剤として有用なマロニル-CoA脱炭酸酵素阻害剤
Document Type and Number:
Japanese Patent JP2004527475
Kind Code:
A
Abstract:
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.
Inventors:
Argenius Thomas
Chen Me
Cheng Chi Fay
Fan uchin
Nathan alex
Penn Richard
Warrant David
Tsang Lin
Chen Me
Cheng Chi Fay
Fan uchin
Nathan alex
Penn Richard
Warrant David
Tsang Lin
Application Number:
JP2002559032A
Publication Date:
September 09, 2004
Filing Date:
January 22, 2002
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
A61K31/045; A61K31/095; A61K31/133; A61K31/137; A61K31/16; A61K31/165; A61K31/341; A61K31/41; A61K31/415; A61K31/4164; A61K31/42; A61K31/426; A61K31/427; A61K31/433; A61K31/44; A61K31/4439; A61K31/444; A61K31/454; A61K31/505; A61K31/5375; A61K31/55; A61K31/664; A61P3/04; A61P3/10; A61P3/12; A61P9/00; A61P9/04; A61P9/10; A61P35/00; A61P43/00; C07C33/48; C07C215/24; C07C233/22; C07C307/10; C07C323/14; C07D233/54; C07D239/42; C07D261/04; C07D261/08; C07D277/20; C07D277/46; C07D277/48; C07D277/52; C07D285/135; C07D307/46; C07D401/12; C07D413/04; C07D413/06; C07D413/12; C07D417/12; C07D417/14; C07D487/08; C07D498/08; C07F9/24; C07F9/6539; C07D285/12; (IPC1-7): C07D239/42; A61K31/045; A61K31/095; A61K31/133; A61K31/137; A61K31/165; A61K31/341; A61K31/42; A61K31/426; A61K31/427; A61K31/433; A61K31/4439; A61K31/444; A61K31/454; A61K31/505; A61K31/55; A61K31/664; A61P3/04; A61P3/10; A61P3/12; A61P9/00; A61P9/04; A61P9/10; A61P35/00; A61P43/00; C07C233/22; C07D261/04; C07D277/20; C07D277/46; C07D277/52; C07D285/135; C07D307/46; C07D413/04; C07D413/12; C07D417/12; C07D417/14; C07D487/08; C07F9/24
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Kazunori Hashimoto