Title:
発酵による精密化学物質の製造方法
Document Type and Number:
Japanese Patent JP2007514439
Kind Code:
A
Abstract:
The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i. e., glycerol kinase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of glycerol kinase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
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Inventors:
Zelder, oscar
Croplogge, Corinna
Schrader, Hartwig
Haefner, stephan
Craiger, Burghard
Kiefer, Patrick
Heinzul, Elmer
Wittmann, Christoph
Croplogge, Corinna
Schrader, Hartwig
Haefner, stephan
Craiger, Burghard
Kiefer, Patrick
Heinzul, Elmer
Wittmann, Christoph
Application Number:
JP2006544606A
Publication Date:
June 07, 2007
Filing Date:
December 17, 2004
Export Citation:
Assignee:
BASF Aktiengesellschaft
International Classes:
C12N1/21; C12N15/09; C12P13/08; C12P
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita