Title:
レイン及びジアセレインの製造法
Document Type and Number:
Japanese Patent JP4379832
Kind Code:
B2
Abstract:
The following description sets forth a process for producing rhein, diacerhein and other diacyl derivatives thereof, which comprises the following steps: treatment of a diphenylketone in which R1 is -OR', -NR'R'', -SR', where R' and R'' are H, an alkyl or aromatic group; R2 is H or a protective group. R3 is -OH or C1-C4 alkyl, with an acid or superacid to give a 1-aminoanthraquinone derivative, diazotisation, replacement of the -NH2 group by -OH, optional removal of the protective group, and acylation.
Inventors:
Guido di Naples
Application Number:
JP19842397A
Publication Date:
December 09, 2009
Filing Date:
July 24, 1997
Export Citation:
Assignee:
LABORTOILE MEDIUM S.A.
International Classes:
A61K8/30; A61K8/00; C07C51/367; A61K8/35; A61K8/36; A61K8/368; A61K8/41; A61K31/19; A61P43/00; A61Q19/00; C07C51/06; C07C51/09; C07C51/353; C07C51/373; C07C66/02; C07C67/00; C07C69/02; C07C69/16; C07C69/95; C07C227/20; C07C229/66; C07C229/74; C07C237/30; C07C237/40; C07C245/20; C07C327/16; C07C327/26
Domestic Patent References:
| JP52062262A | ||||
| JP52128229A | ||||
| JP58225015A |
Other References:
A.C.Bellaart, C.Koningsberger,A synthesis of 1-Hydroxy-8-methoxyanthraquinone-3-carboxylic acid.,Recueil des Travaux Chimiques des Pays-Bas,NL,1960年,vol.79,p.1289-1292
KENDE,A.S. et al,Regiospecific synthesis of 1,4,5-trioxygenated anthraquinones. Total synthesis of islandicin,Tetrahedron Letters,1973年,No.31,p.2935-8
NEWMAN,M.S.,Spirocyclic intermediates in organic reactions,Accounts of Chemical Research,1972年,Vol.5, No.10,p.354-60
STANLEY J. CRISTOL, et al.,rneso-Dihydroanthracene Chemistry. 11. The Preparationof 1,5- and 1 ,8-Dimethylanthraquinones1,The Journal of Organic Chemistry,1968年 5月,Vol.35, No.5,p.2020-2025
Andreas Opitz, et al.,Regioselective Synthesis of Benzo[g]isoquinoline-5,10-dioneDerivatives as DNA Intercalators,Tetrahedron,2000年,Vol.56 ,p.5147-5155
CHANDRASENAN,K. et al,A new synthesis of catenarin and erythroglaucin,Proceedings - Indian Academy of Sciences, Section A,1960年,Vol.51A, 296-300,p.51A, 296-300
KENDE,A.S. et al,Regiospecific synthesis of 1,4,5-trioxygenated anthraquinones. Total synthesis of islandicin,Tetrahedron Letters,1973年,No.31,p.2935-8
NEWMAN,M.S.,Spirocyclic intermediates in organic reactions,Accounts of Chemical Research,1972年,Vol.5, No.10,p.354-60
STANLEY J. CRISTOL, et al.,rneso-Dihydroanthracene Chemistry. 11. The Preparationof 1,5- and 1 ,8-Dimethylanthraquinones1,The Journal of Organic Chemistry,1968年 5月,Vol.35, No.5,p.2020-2025
Andreas Opitz, et al.,Regioselective Synthesis of Benzo[g]isoquinoline-5,10-dioneDerivatives as DNA Intercalators,Tetrahedron,2000年,Vol.56 ,p.5147-5155
CHANDRASENAN,K. et al,A new synthesis of catenarin and erythroglaucin,Proceedings - Indian Academy of Sciences, Section A,1960年,Vol.51A, 296-300,p.51A, 296-300
Attorney, Agent or Firm:
Jyohei Yamashita