Title:
N,N‘-二置換オキサビスピジン類の製造プロセス
Document Type and Number:
Japanese Patent JP2009501702
Kind Code:
A
Abstract:
There is provided a process for the preparation of a sulfonic acid salt of formula I, or a solvate thereof, which process comprises hydrogenating a sulfonic acid salt of formula II, or a solvate thereof; in the presence of a solvent system consisting essentially of water, a C3-5 secondary alkyl alcohol and no more than 15% v/v of another organic solvent, wherein the sulfonic acid salt of formula I is optionally, without isolation, converted to a compound of formula IX, or a pharmaceutically-acceptable derivative thereof, wherein R1, R2, R3, R6, R7, R8, A, B and D have meanings given in the description.
Inventors:
Cladding Boel, David
Gareth
Gareth
Application Number:
JP2008518071A
Publication Date:
January 22, 2009
Filing Date:
June 12, 2006
Export Citation:
Assignee:
AstraZeneca Activrag
International Classes:
C07D498/08; C07D303/22; A61K31/5386; A61P9/06; C07C303/32; C07C309/30; C07C309/39
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Ken Matsumoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Ken Matsumoto