Title:
Medicine for malignant tumor transition control
Document Type and Number:
Japanese Patent JP5948683
Kind Code:
B2
Abstract:
The present invention relates to a natriuretic peptide receptor GC-B agonist for use in preventing or suppressing the metastasis of a malignant tumor, wherein the natriuretic peptide receptor GC-B agonist is any one selected from the following (b1) to (b5) or a pharmacologically acceptable salt thereof and has an agonist activity for the natriuretic peptide receptor GC-B: (b1) a c-type natriuretic peptide consisting of the amino acid sequence of SEQ ID NO: 7, 8, 9 or 10, (b2) a substance comprising an active fragment, where in it has the amino acid sequence of SEQ ID NO: 11, or wherein it consists of the amino acid sequence from position 6 to position 22 of SEQ ID NO: 7, (b3) a mutant wherein it is (i) a peptide consisting of the amino acid sequence of SEQ ID NO: 7, 9 or 10 having substitution, deletion, insertion, and/or addition of one to several amino acids selected from positions 1 to 5, (ii) a peptide consisting of the amino acid sequence of SEQ ID NO: 8 having substitution, deletion, insertion, and/or addition of one to several amino acids at any one to several positions selected from positions 1 to 36: (b4) a derivative comprising any one of the amino acid sequences of SEQ ID Nos: 7 to 11, wherein the derivative preferably further comprises at least one of the Fc region of an immunoglobulin, a serum albumin, and the C-terminus of ghrelin, and (b5) a modified form wherein it comprises any one of the amino acid sequences of SEQ ID Nos: 7 to 10 of the sequence listing, and at least one amino acid other than the amino acids shown in SEQ ID NO: 11 is chemically modified, or wherein it is prepared by chemical modification by addition of a pharmaceutically usable polymer.
Inventors:
Kenji Samukawa
Yoji Hosoda
Takashi Nojiri
Akiyuki Okumura
Yoji Hosoda
Takashi Nojiri
Akiyuki Okumura
Application Number:
JP2013502349A
Publication Date:
July 06, 2016
Filing Date:
February 27, 2012
Export Citation:
Assignee:
National Cardiovascular Research Center
National University Corporation Osaka University
Shionogi Pharmaceutical Co., Ltd.
National University Corporation Osaka University
Shionogi Pharmaceutical Co., Ltd.
International Classes:
A61K45/00; A61K38/22; A61K47/30; A61K47/42; A61K47/48; A61P35/04; A61P43/00
Domestic Patent References:
| JP2008509900A | 2008-04-03 | |||
| JP2008500944A | 2008-01-17 | |||
| JP2009519215A | 2009-05-14 | |||
| JP2005527510A | 2005-09-15 | |||
| JP2004532208A | 2004-10-21 |
Other References:
JPN6012017531; ＫＯＮＧ， Ｘ．， ｅｔ ａｌ．: 'Ｎａｔｒｉｕｒｅｔｉｃ Ｐｅｐｔｉｄｅ Ｒｅｃｅｐｔｏｒ Ａ ａｓ ａ Ｎｏｖｅｌ Ａｎｔｉｃａｎｃｅｒ Ｔａｒｇｅｔ' Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ．６８， Ｎｏ．１, 20080101, ｐ．２４９-２５６
JPN6015050276; 日本消化器学会雑誌 Ｖｏｌ．９８ 臨時増刊号総会, 2001, ｐ．Ａ４６
JPN6015050278; ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．２７６， Ｎｏ．５０, 2001, ｐ．４６８７０-４６８７７
JPN6015050281; Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｏｌｏｇｙ Ｖｏｌ．３５４， Ｎｏ．１, 1998, ｐ．９９-１０４
JPN6015050284; Ｊｏｕｒｎａｌ ｏｆ Ａｌｌｅｒｇｙ ａｎｄ Ｃｌｉｎｉｃａｌ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．１１４， Ｎｏ．３, 2004, ｐ．５２０-５２６
JPN6015050276; 日本消化器学会雑誌 Ｖｏｌ．９８ 臨時増刊号総会, 2001, ｐ．Ａ４６
JPN6015050278; ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．２７６， Ｎｏ．５０, 2001, ｐ．４６８７０-４６８７７
JPN6015050281; Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｏｌｏｇｙ Ｖｏｌ．３５４， Ｎｏ．１, 1998, ｐ．９９-１０４
JPN6015050284; Ｊｏｕｒｎａｌ ｏｆ Ａｌｌｅｒｇｙ ａｎｄ Ｃｌｉｎｉｃａｌ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．１１４， Ｎｏ．３, 2004, ｐ．５２０-５２６
Attorney, Agent or Firm:
Ryu Iwatani