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Title:
CCR2受容体アンタゴニストとしてのメルカプトイミダゾール
Document Type and Number:
Japanese Patent JP2008500310
Kind Code:
A
Abstract:
The present invention relates to a compound of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine, a polymorphic form or a stereochemically isomeric form thereof, wherein R1 represents hydrogen, C1-6alkyl, C3-7cycloalkyl, C1-6alkyloxyC1-6alkyl, di(C1-6alkyl)aminoC1-6alkyl, aryl or heteroaryl; each R2 independently represents halo, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio, polyhaloC1-6alkyl, polyhaloC1-6alkyloxy, cyano, aminocarbonyl, amino, mono- or di(C1-4alkyl)amino, nitro, aryl or aryloxy; R3 represents hydrogen, cyano, optionally substituted C1-6alkyl, C(-O)-O-R5, C(-O)-NR6aR6b, C(-S)-NR6aR6b, S(-O)2-NR6aR6b or C(-O)-R7; R4 represents hydrogen or C1-6alkyl; n is 1, 2, 3, 4 or 5; Z represents a cyclic ring system. The invention also relates to processes for preparing the compounds of formula (I), their use as CCR2 antagonists and pharmaceutical compositions comprising them.

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Inventors:
Bex, Gustav Maria
Van Lomen, Guy Rosalia Eugene
Doyon, Giulian Giorgijo Pierre-Olivier
Kosemann, Elvin
Application Number:
JP2007513921A
Publication Date:
January 10, 2008
Filing Date:
May 24, 2005
Export Citation:
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Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D233/84; A61K31/4164; A61K31/4178; A61K31/42; A61K31/422; A61K31/4245; A61K31/427; A61K31/433; A61K31/4439; A61K31/497; A61K31/501; A61K31/502; A61P1/04; A61P1/16; A61P3/10; A61P9/10; A61P9/14; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P25/00; A61P25/04; A61P25/28; A61P27/14; A61P29/00; A61P31/04; A61P31/18; A61P35/00; A61P37/00; A61P37/06; A61P37/08; A61P43/00; C07C211/29; C07D233/90; C07D401/04; C07D403/04; C07D409/04; C07D413/04; C07D417/04; C07D417/06
Attorney, Agent or Firm:
Heikichi Odashima



 
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