Title:
代謝が最適化された細胞培養
Document Type and Number:
Japanese Patent JP6967620
Kind Code:
B2
Abstract:
An improved method for large scale production of proteins and/or polypeptides in cell culture is provided. In accordance with the present invention, the method provides for culturing cells that have metabolically shifted. The use of such a method or system allows high levels of protein or polypeptide production and reduces accumulation of unwanted metabolic waste such as lactate. Proteins and polypeptides expressed in accordance with the present invention may be advantageously used in the preparation of pharmaceutical, immunogenic, or other commercial biologic compositions, such as antibodies.
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Inventors:
Sean Lawrence
Ankim
Amy Johnson
Ankim
Amy Johnson
Application Number:
JP2020024484A
Publication Date:
November 17, 2021
Filing Date:
February 17, 2020
Export Citation:
Assignee:
REGENERON PHARMACEUTICALS, INC.
International Classes:
C12P21/02; C12N5/12; C12N5/18; C12N5/22; C12P21/08
Foreign References:
| US20030113915 |
Other References:
Biotechnology and Bioengineering,2013年07月,Vol.110, No.7,p.2013-2024
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita
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