Title:
ケトン類化合物を不斉水素添加する方法
Document Type and Number:
Japanese Patent JP5902577
Kind Code:
B2
Abstract:
The invention relates to an asymmetric hydrogenation method for ketone compounds, comprising the step of: under hydrogen atmosphere, in the presence of an in situ catalyst derived from a chiral ligand and a ruthenium salt, adding a ketone compound and a base into a second solvent to carry out an asymmetric hydrogenation for the ketone compound. The invention can obtain a conversion of 100% and a highest asymmetric inducement effect of 99.7% for the ketone compound. The invention has the advantages including simple procedure, high conversion and selectivity, good atom economy and good prospect of industrial application.
Inventors:
Zhang Wan
Liu Delong
Teru Guo
Liu Yan Go
Liu Delong
Teru Guo
Liu Yan Go
Application Number:
JP2012164529A
Publication Date:
April 13, 2016
Filing Date:
July 25, 2012
Export Citation:
Assignee:
Nippon Chemical Industry Co., Ltd.
International Classes:
C07C29/145; B01J31/24; C07B53/00; C07C33/18; C07C33/22; C07C33/24; C07C33/46; C07C35/32; C07C35/36; C07C37/00; C07C39/11; C07C41/26; C07C43/23; C07C213/00; C07C215/68; C07D213/30; C07D307/42
Domestic Patent References:
| JP2009529569A | ||||
| JP9059290A | ||||
| JP2009539781A | ||||
| JP2009525304A |
Foreign References:
| WO2009125565A1 | ||||
| CN1876666A | ||||
| WO2009043300A1 | ||||
| CN1876667A | ||||
| CN1876668A |
Other References:
Tetrahedron Letters,1996年,Vol.37, No.44,p.7995-7998
Attorney, Agent or Firm:
Showa International Patent Office
Osamu Hatori
Yoshiyuki Matsushima
Osamu Hatori
Yoshiyuki Matsushima