Title:
大腸癌発症可能性の判定方法
Document Type and Number:
Japanese Patent JP7094881
Kind Code:
B2
Abstract:
The present invention provides a method for determining the likelihood of colorectal cancer development in a human ulcerative colitis patient, the method including: a measurement step of measuring methylation rates of one or more CpG sites present in specific differentially methylated regions in DNA recovered from a biological sample collected from the human ulcerative colitis patient; and a determination step of determining the likelihood of colorectal cancer development in the human ulcerative colitis patient based on average methylation rates of the differentially methylated regions which are calculated based on the methylation rates measured in the measurement step and a preset reference value or a preset multivariate discrimination expression, in which the reference value is a value for identifying a cancerous ulcerative colitis patient and a non-cancerous ulcerative colitis patient, which is set for the methylation rate of each differentially methylated region, and the multivariate discrimination expression includes, as variables, average methylation rates of one or more differentially methylated regions among the specific differentially methylated regions.
Inventors:
Kusunoki Masato
Yuji Qiyama
Koji Tanaka
Araki Toshimitsu
Mitsui Akira
Kenji Takehana
Tsutomu Umezawa
Yuji Qiyama
Koji Tanaka
Araki Toshimitsu
Mitsui Akira
Kenji Takehana
Tsutomu Umezawa
Application Number:
JP2018526453A
Publication Date:
July 04, 2022
Filing Date:
July 07, 2017
Export Citation:
Assignee:
Hanumat Co., Ltd.
ea pharma corporation
ea pharma corporation
International Classes:
C12M1/26; A61B10/02; C12N15/11; G01N33/50
Domestic Patent References:
| JP2003235799A | ||||
| JP2015006164A | ||||
| JP2014140377A |
Foreign References:
| WO2015153283A1 | ||||
| WO2014026768A1 |
Other References:
Codmanマイクロピンセット,医療機器添付文書[オンライン],2009年06月19日,届出番号: 13B1X00204MC009, [検索日 2017.08.04], インターネット:
KIBRIYA, MG. et al.,A genome-wide DNA methylation study in colorectal carcinoma,BMC Medical Genomics, 2011, 4:50, p.1-16,Abstract,DOI: 10.1186/1755-8794-4-50
KIBRIYA, MG. et al.,A genome-wide DNA methylation study in colorectal carcinoma,BMC Medical Genomics, 2011, 4:50, p.1-16,Abstract,DOI: 10.1186/1755-8794-4-50
Attorney, Agent or Firm:
田▲崎▼ 聡
Kazuyuki Iwahashi
Hirotaka Haruta
Kazuyuki Iwahashi
Hirotaka Haruta