Title:
ニコチンアミドモノヌクレオチド結晶の嵩密度を向上させる方法及びその結晶
Document Type and Number:
Japanese Patent JP7479035
Kind Code:
B2
Abstract:
A method for increasing the bulk density of a crystal of nicotinamide mononucleotide (NMN), and a crystal of NMN. The method comprises: dissolving NMN in water to obtain an aqueous solution of NMN; subjecting the aqueous solution of NMN to concentration under reduced pressure or freeze drying same to obtain a semisolid with a water content of less than 15%; adding a solventing-out agent to the semisolid in a dropwise manner while stirring same, and at the same time, cooling same to a terminal crystallization temperature of 5°C - 18°C at a cooling rate of 1°C/h - 15°C/h; and after the crystal is completely precipitated, filtering and drying the crystal to obtain the crystal of NMN having an increased bulk density. A crystal of NMN having a bulk structure can be prepared by means of the method, and the bulk density of the crystal of NMN is increased by multiple times compared with the existing crystal of NMN.
Inventors:
Jian Jiang
Chin Min
Jiang Chun Liang
Chin Min
Jiang Chun Liang
Application Number:
JP2022563187A
Publication Date:
May 08, 2024
Filing Date:
November 08, 2021
Export Citation:
Assignee:
Hotai Biological Engineering (Shenzhen) Co., Ltd.
Zhongshan Bangtai Hesheng Biological Technology Co., Ltd.
Zhongshan Bangtai Hesheng Biological Technology Co., Ltd.
International Classes:
C07H19/048; C07H1/06
Foreign References:
| CN113402570A | ||||
| CN112870979A |
Attorney, Agent or Firm:
Ryohei Kaizuka
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