METHOD FOR INDUCING ATRIAL FIBRILLATION

Title:

METHOD FOR INDUCING ATRIAL FIBRILLATION

Document Type and Number:

Japanese Patent JP2011097954

Kind Code:

A

Abstract:

To simply and effectively utilize a paroxysmal atrial fibrillation model animal or rat having human analogous disease developing mechanism, for screening for evaluating medicinal benefits of atrial fibrillation inhibitors (antiarrhythmic).

There is provided a method for inducing atrial fibrillation by giving a stress to the atrium on a condition of administering an anesthetic to a rat to sleep.

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Inventors:

SUGIYAMA ATSUSHI
TAKAHARA AKIRA
HASHIMOTO KEITARO

Application Number:

JP2011015743A

Publication Date:

May 19, 2011

Filing Date:

January 27, 2011

Export Citation:

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Assignee:

TOHO UNIV FOUNDATION

International Classes:

A01K67/00; A61K31/407

Domestic Patent References:

JPH01110345A

1989-04-27

Other References:

JPN6010046287; Ｊａｎｎｉｅ　Ａｕｓｍａ，　Ｎｉｃｏｌｌｅ　Ｌｉｔｊｅｎｓ，　Ｍａｒｉｅ-Ｈｅｌｅｎｅ　Ｌｅｎｄｅｒｓ，　Ｈａｎｓ　Ｄｕｉｍｅｌ，　Ｆｒａｎｓ　Ｍａｓｔ，　Ｌｕｃ　Ｗｏｕｔｅｒｓ，　Ｆｒａｎｓ　Ｒａｍ: 'Ｔｉｍｅ　Ｃｏｕｒｓｅ　ｏｆ　Ａｔｒｉａｌ　Ｆｉｂｒｉｌｌａｔｉｏｎ-ｉｎｄｕｃｅｄ　Ｃｅｌｌｕｌａｒ　Ｓｔｒｕｃｔｕｒａｌ　Ｒｅｍｏｄｅｌｉｎｇ　ｉｎ　Ａｔｒｉａ　ｏｆ　ｔｈｅ　Ｇｏａｔ' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｏｌｅｃｕｌａｒ　ａｎｄ　Ｃｅｌｌｕｌａｒ　ＣａｒｄｉｏｌｏｇｙＶｏｌ．３３，　Ｎｏ．１&
JPN6013023624; Ｍａｕｒｉｔｓ　Ｃ．Ｅ．Ｆ．　Ｗｉｊｆｆｅｌｓ，　Ｃｈａｒｌｅｓ　Ｊ．Ｈ．Ｊ．　Ｋｉｒｃｈｈｏｆ，　Ｒｉｃｋ　Ｄｏｒｌａｎｄ，　Ｍａｕｒｉｔｓ　Ａ．　Ａｌｌｅｓｓｉｅ: 'Ａｔｒｉａｌ　Ｆｉｂｒｉｌｌａｔｉｏｎ　Ｂｅｇｅｔｓ　Ａｔｒｉａｌ　Ｆｉｂｒｉｌｌａｔｉｏｎ　　Ａ　Ｓｔｕｄｙ　ｉｎ　Ａｗａｋｅ　Ｃｈｒｏｎｉｃａｌｌｙ　Ｉｎｓｔｒｕｍｅｎｔｅｄ　Ｇｏａｔｓ' ＣｉｒｃｕｌａｔｉｏｎＶｏｌ．９２, 1995, ｐｐ．１９５４-１９６８
JPN6010046287; Ｊａｎｎｉｅ　Ａｕｓｍａ，　Ｎｉｃｏｌｌｅ　Ｌｉｔｊｅｎｓ，　Ｍａｒｉｅ-Ｈｅｌｅｎｅ　Ｌｅｎｄｅｒｓ，　Ｈａｎｓ　Ｄｕｉｍｅｌ，　Ｆｒａｎｓ　Ｍａｓｔ，　Ｌｕｃ　Ｗｏｕｔｅｒｓ，　Ｆｒａｎｓ　Ｒａｍ: 'Ｔｉｍｅ　Ｃｏｕｒｓｅ　ｏｆ　Ａｔｒｉａｌ　Ｆｉｂｒｉｌｌａｔｉｏｎ-ｉｎｄｕｃｅｄ　Ｃｅｌｌｕｌａｒ　Ｓｔｒｕｃｔｕｒａｌ　Ｒｅｍｏｄｅｌｉｎｇ　ｉｎ　Ａｔｒｉａ　ｏｆ　ｔｈｅ　Ｇｏａｔ' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｏｌｅｃｕｌａｒ　ａｎｄ　Ｃｅｌｌｕｌａｒ　ＣａｒｄｉｏｌｏｇｙＶｏｌ．３３，　Ｎｏ．１&

Attorney, Agent or Firm:

Koichi Hirota
Yoshihiro Nagare
Naoko Matsuda

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