Title:
リストセチン非存在下のフォンビルブラント因子活性の測定方法及びＡＤＡＭＴＳ−１３プロテアーゼの測定方法
Document Type and Number:
Japanese Patent JP5745270
Kind Code:
B2
Abstract:
Determining von Willebrand factor activity comprises mixing a sample with a human GPIbalpha protein (I) having amino acid substitutions at positions 233 and 239 and not adding ristocetin or botrocetin. Independent claims are also included for: (1) test kit for an assay as above, comprising (I) on a nonparticulate solid phase; (2) producing (I) by expressing (I) recombinantly in a prokaryotic or eukaryotic cell culture and isolating (I) from a cell lysate or culture supernatant by affinity chromatography.
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Inventors:
Harald Altaoche
Tobias Observer
Juergen Patzke
Reinhard Schneppenheim
Tobias Observer
Juergen Patzke
Reinhard Schneppenheim
Application Number:
JP2010513781A
Publication Date:
July 08, 2015
Filing Date:
July 03, 2008
Export Citation:
Assignee:
Siemens, Healthcare, Diagnostics, Products, Game Behr
International Classes:
G01N33/53; G01N33/49
Foreign References:
| WO2001002853A1 | ||||
| WO2006120030A1 |
Other References:
A. Sasha Tait,Phenotype changes resulting in high-affinity binding of von Willebrand factor to recombinant glycoprotein Ib-IX: analysis of the platelet-type von Willebrand disease mutations,Blood,米国,2001年,Vol. 98; 1812-1818
Shuji Miura,Interaction of von Willebrand Factor Domain A1 with Platelet Glycoprotein Ib a-(1-289):SLOW INTRINSIC BINDING KINETICS MEDIATE RAPID PLATELET ADHESION,The Journal of Biological Chemistry,2000年 3月17日,Vol.275,pp.7539-7546
Shuji Miura,Interaction of von Willebrand Factor Domain A1 with Platelet Glycoprotein Ib a-(1-289):SLOW INTRINSIC BINDING KINETICS MEDIATE RAPID PLATELET ADHESION,The Journal of Biological Chemistry,2000年 3月17日,Vol.275,pp.7539-7546
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi