Title:
METHOD FOR MINIMIZING LIVER REPERFUSION INJURY
Document Type and Number:
Japanese Patent JPH08104626
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To minimize hepatic reperfusion injury in a patient following surgery by using an ω-3-polyunsaturated fatty acid in a form such as of fish oil that is protected so that an effective level of peroxidation may not occur in the patient. SOLUTION: ω-3-polyunsaturated fatty acids(PuFA) is protected so that the polyunsaturated fatty acids may not cause peroxidation, particularly by capsulation or mixing with vitamin C and vitamin E and its effective dose is administered to a preoperative patient needing treating as a preoperative diet thereby minimizing the hepatic reperfusion injury. Starch is suitable as a pharmaceutically acceptable microcapsulating agent, further, those microcapsules may be coated with a coating agent as gum Arabic. The ω-3PuFA is, for example, linseed oil, Menhaden-oil, salmon oil, mackerel oil, cod liver oil or anchovy oil. In a preferred embodiment, the ω-3PuFA is eicosapentaenoic acid.
Inventors:
HAINTSU SHIYUNAIDAA
RONARUDO JII SAAMAN
RONARUDO JII SAAMAN
Application Number:
JP24594295A
Publication Date:
April 23, 1996
Filing Date:
September 25, 1995
Export Citation:
Assignee:
SANDOZ NUTRITION LTD
International Classes:
A23L1/30; A61K9/48; A61K31/20; A61K31/202; A61K35/60; A61K47/10; A61K47/12; A61P1/16; A61P3/00; A61P9/00; A61P43/00; (IPC1-7): A61K31/20; A23L1/30; A61K9/48; A61K31/20; A61K35/60; A61K47/10; A61K47/12
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)