Title:
METHOD FOR PRODUCING 4-CYANOCYCLOHEXANE-1-CARBOXYLIC ACID
Document Type and Number:
Japanese Patent JP2008260757
Kind Code:
A
Abstract:
To provide an inexpensive and efficient method for producing 4-cyanocyclohexane-1-carboxylic acid useful as an intermediate for producing tranexamic acid.
4-Cyanocyclohexane-1-carboxylic acid is inexpensively and efficiently produced by irradiating a mixture of 1,4-cyclohexanedicarboxylic acid and 1,4-dicyanocyclohexane with a microwave. 4-Cyanocyclohexane-1-carboxylic acid is catalytically reduced, and the obtained compound is treated with an alkali or ammonia and led to trans-4-aminomethylcyclohexanecarboxylic acid, namely tranexamic acid known as an antiplasmin agent.
Inventors:
SATO YUKIO
HATANAKA AKINORI
HATANAKA AKINORI
Application Number:
JP2008055651A
Publication Date:
October 30, 2008
Filing Date:
March 06, 2008
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD
International Classes:
C07C253/30; C07C227/06; C07C229/46; C07C255/46
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto