Title:
活性成分含有粒子を押出し及び凍結乾燥によって製造する方法
Document Type and Number:
Japanese Patent JP3601825
Kind Code:
B2
Abstract:
A method for preparing particles each of which consists of a carrier forming a matrix, and at least one active ingredient uniformly distributed throughout said matrix. The method comprises extrusion and freeze-drying steps, wherein 1) (a) at least one active ingredient, (b) a physiologically acceptable hydrophilic carrier, and (c) water are uniformly mixed to give a pasty mixture with a viscosity at room temperature (15-20 DEG C) of under 1 Pa.s; 2) the resulting uniform mixture is extruded and the extrudate is broken up into moist particles; 3) the resulting particles are frozen as they fall under their own weight into an inert gas stream at a below-zero temperature; and 4) said particles are freeze-dried.
Inventors:
Nguyen Tan-Tom
Jaco-Reide Joel
Jaco-Reide Joel
Application Number:
JP52071094A
Publication Date:
December 15, 2004
Filing Date:
March 15, 1994
Export Citation:
Assignee:
Labor Toile El Lafon
International Classes:
A23P1/02; A61J3/06; A61K9/14; A61K9/16; A61K9/19; B01J2/04; F26B5/06; B01J2/20; B29C47/00; C08J9/28; F25C1/00; (IPC1-7): A61J3/06; A23P1/02; A61K9/14; B29C47/00; C08J9/28; F26B5/06
Domestic Patent References:
| JP1030615A | ||||
| JP61260029A | ||||
| JP4212359A | ||||
| JP5495720A |
Foreign References:
| US4230687 | ||||
| GB2133983A |
Attorney, Agent or Firm:
Tetsuo Hotaka