抗体薬物複合体の製造方法

Japanese Patent JP7364584

B2

The present invention provides a method for producing an antibody-drug conjugate (ADC) comprising an antibody and a drug linked to each other via a linker. The present invention provides a method for producing, for example, an antibody-drug conjugate (ADC) comprising an antibody and a drug linked to each other via a linker, or a pharmaceutical comprising the ADC, the method comprising mixing, using a microreactor, a solution comprising tricarboxyethyl phosphine (TCEP) and an IgG antibody under reduction reaction with TCEP, with a solution comprising a stoichiometrically excessive amount of an inhibitor of TCEP based on TCEP.

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Masato Suenaga
Kosuke Takenaka
Keiji Iwamoto

JP2020551231A

October 18, 2023

October 10, 2019

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Takeda GmbH

A61K47/68; A61K31/427; A61K39/395; A61P35/00

JP2017189729A
JP2016531914A
JP2008501029A

WO2017179353A1

ACS Omega,2017年,2,p.5785-5791
Bioconjugate Chem.,2016年,27,p.2260-2265
DORONINA S.O. et al.,Development of potent monoclonal antibody auristatin conjugates for cancer therapy,Nature Biotechnology,2003年07月,21(7),p.778-784

Seiji Ohno
Yuko Matsutoya
Shinsuke Umeda
Hiroshi Morita
Chisuke Konno
Nobuto Oki

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