Title:
ＣＤ８α＋β＋細胞傷害性Ｔ細胞の製造方法
Document Type and Number:
Japanese Patent JP7136454
Kind Code:
B2
Abstract:
A method of efficiently producing cytotoxic T lymphocytes having intrinsic properties of lymphocytes of the acquired immune system suitable for cellular immunotherapy is provided. A method of producing D8α+β+ cytotoxic T lymphocytes, comprising the step of culturing CD4/CD8 double-positive T cells in a medium containing IL-7 and a T-cell receptor activator, to induce CD8α+β+ cytotoxic T lymphocytes.
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Inventors:
Kaneko Shin
Yohei Kawai
Yohei Kawai
Application Number:
JP2018562467A
Publication Date:
September 13, 2022
Filing Date:
January 19, 2018
Export Citation:
Assignee:
Kyoto University
International Classes:
C12N5/0783; C12N5/0735; C12N5/10
Domestic Patent References:
| JP2014526244A | ||||
| JP2008521406A |
Foreign References:
| WO2016076415A1 | ||||
| WO2005019450A1 |
Other References:
Cancer Research, 2016, Vol.76, No.23, pp.6839-6850
Int. J. Mol. Sci., 2015, Vol.16, pp.8744-8760
日本癌学会学術総会記事, 2008, Vol.67, p.449, P-8287
日本免疫学会総会・学術集会記録, 2005, Vol.35, p.95, 1-F-W11-20-P
Int. J. Mol. Sci., 2015, Vol.16, pp.8744-8760
日本癌学会学術総会記事, 2008, Vol.67, p.449, P-8287
日本免疫学会総会・学術集会記録, 2005, Vol.35, p.95, 1-F-W11-20-P
Attorney, Agent or Firm:
Hidewa Patent Office