Title:
METHOD FOR PRODUCING OPTICALLY ACTIVE β-AMINO ACID DERIVATIVE
Document Type and Number:
Japanese Patent JP2003146955
Kind Code:
A
Abstract:
To provide a method for producing an optically active β-aminoacid derivative in high yield and high stereoselectivity by asymmetrically hydrogenating a 3-aminoacrylic acid derivative at a low hydrogen pressure without using an expensive asymmetric ligand.
An 3-aminoacrylic acid derivative is asymmetrically hydrogenated by the catalytic action of a complex of an optically active bis(alkylmethylphosphino)-ethane or an optically active bis (alkylmethylphosphino)-methane which can readily be prepared with a transition metal, particularly an optically active bis(tert-butylmethylphosphino)ethane- rhodium complex or an optically active bis (tert-butylmethylphosphino)methane- rhodium complex.
Inventors:
YASUTAKE SEIYA
ILIA DIMITRIEVICH GRIDNEV
AZUMA NATSUKA
IMAMOTO TSUNEO
SUGAWARA MASANOBU
INOUE KENJI
ILIA DIMITRIEVICH GRIDNEV
AZUMA NATSUKA
IMAMOTO TSUNEO
SUGAWARA MASANOBU
INOUE KENJI
Application Number:
JP2001343360A
Publication Date:
May 21, 2003
Filing Date:
November 08, 2001
Export Citation:
Assignee:
KANEGAFUCHI CHEMICAL IND
International Classes:
C07C231/18; C07B53/00; C07B61/00; C07C233/46; C07C233/51; (IPC1-7): C07C231/18; C07C233/46; C07C233/51
Attorney, Agent or Firm:
Yasuo Yasutomi (1 outside)
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