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Title:
有機金属複合体及びアルドール付加体の製造方法
Document Type and Number:
Japanese Patent JP4224590
Kind Code:
B2
Abstract:

To provide an organometallic complex having excellent properties as a catalyst for a Mukaiyama aldol reaction.

THF (5 mL) is added to a Schlenk reaction flask to which sodium phenoxide (0.025 mmol) and 1,2-bis(diphenyl-phosphoryl)benzene (0.050 mmol) are inserted in nitrogen atmosphere, and the resultant mixture is stirred for 10 min at room temperature. Thereafter, the solution is cooled to -78°C, and stirred for 5 min. Methyl trimethylsilyl dimethyl ketene acetal (3.0 mmol) as silyl enolate and benzophenone (2.5 mmol) are added to the same solution, and the resultant mixture is stirred at -78°C for 2 hr to afford an aldol adduct having two neighboring quaternary carbons in 97% yield.

COPYRIGHT: (C)2008,JPO&INPIT


Inventors:
Kazuaki Ishihara
Hatano Manabu
Application Number:
JP2007018431A
Publication Date:
February 18, 2009
Filing Date:
January 29, 2007
Export Citation:
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Assignee:
Nagoya University
International Classes:
C07F9/02; B01J31/02; C07C45/45
Domestic Patent References:
JP2268131A
Attorney, Agent or Firm:
Aitec International Patent Office