Title:
方法
Document Type and Number:
Japanese Patent JP2008525395
Kind Code:
A
Abstract:
A process for the preparation of a compound of Formula (1) wherein Ar represents an optionally substituted hydrocarbyl or an optionally substituted heterocyclyl group comprising an aromatic moiety; and R1 and R2 each independently represent an optionally substituted hydrocarbyl or an optionally substituted heterocyclyl group; said process comprising: a) reducing a compound of Formula (2) to form a compound of Formula (3): b) activating the compound of Formula (3) to form a compound of Formula (4): wherein OX represents a leaving group; and c) coupling the compound of Formula (4) to a compound of Formula (5): to form a compound of Formula (1). A stereoselective reduction of ketones to alcohols is also disclosed.
Inventors:
Hodges, George Robert
Martin, Juliet
Hamil, Noel Anthony
Hawthorne, Ian Nicolas
Martin, Juliet
Hamil, Noel Anthony
Hawthorne, Ian Nicolas
Application Number:
JP2007547618A
Publication Date:
July 17, 2008
Filing Date:
December 14, 2005
Export Citation:
Assignee:
Avecia Pharmaceuticals Limited
International Classes:
C07C209/22; C07B53/00; C07C29/143; C07C33/46; C07C209/16; C07C211/29; C07B61/00
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroaki Noya
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroaki Noya