Title:
ゲノム編集効率を高めるための方法、組成物及びキット
Document Type and Number:
Japanese Patent JP7033583
Kind Code:
B2
Abstract:
Methods of editing a target genomic region(s), methods of repairing of a DNA break via a HDR pathway, methods of inhibiting or suppressing repair of a DNA break via a NHEJ pathway, and methods of modifying expression of a gene(s) or protein(s) comprise administering to one or more cells that include one or more target genomic regions, a genome editing system and a DNA protein-kinase (DNAPK) inhibitor disclosed herein. Kits and compositions for editing a target gene comprise a genome editing system and a DNAPK inhibitor disclosed herein.
Inventors:
Abdul-Manan, Nosehan
Newsom, David A.
Zwaren, Jack
Newsom, David A.
Zwaren, Jack
Application Number:
JP2019501575A
Publication Date:
March 10, 2022
Filing Date:
July 13, 2017
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
C12N15/09; A61K48/00; B82Y5/00; C12N15/86; C12N15/861; C12N15/864; C12N15/867; C12N15/869
Domestic Patent References:
| JP2015514804A | ||||
| JP2015534817A |
Foreign References:
| WO2015058067A1 | ||||
| WO2016081923A2 |
Other References:
Genome Medicine,2015年,7: 93,pp. 1-11
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki