Title:
細胞を検出する方法、およびこれに有用な薬剤
Document Type and Number:
Japanese Patent JP5847755
Kind Code:
B2
Abstract:
The present invention relates generally to a method for detecting an aberrant cell, and more particularly an apoptotic cell, in a subject or in a biological sample from said subject, and agents useful for same. The presence of the aberrant cell or group of aberrant cells provides an indication of a particular disease or condition or a propensity for development of a disease or condition. More particularly, the present invention contemplates a method for detecting an apoptotic cell by detecting the presence of extranuclear nuclear molecules, in particular La, or a relative increase in extranuclear nuclear molecule levels. The present invention further provides a method for diagnosing or monitoring conditions characterised by aberrant, unwanted or otherwise inappropriate cellular apoptosis in a subject or in a biological sample from said subject by screening for up-regulation of extranuclear nuclear molecule levels in a cell or group of cells. The present invention provides diagnostic agents useful for detecting these molecules. Such diagnostic agents include immunointeractive molecules, such as antibodies.
Inventors:
Brown michael paul
Application Number:
JP2013088647A
Publication Date:
January 27, 2016
Filing Date:
April 19, 2013
Export Citation:
Assignee:
Medbet Science Pty. Limited
International Classes:
A61K39/395; A61K47/48; A61K51/10; A61P35/00; A61P35/04; A61P43/00; C07K16/18; G01N33/50; G01N33/68
Other References:
Maria-Eugenia Miranda-Carus et al.,'Anti-SSA/Ro and Anti-SSB/La Autoantibodies Bind the Surface of Apoptotic Fetal Cardiocytes and Promote Secretion of TNF-α by Macrophages',The Journal of Immunology,Vol.165, No. 9 (2000) ,pp.5345-5351
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi
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