Title:
METHODS FOR PRODUCING PHARMACEUTICAL COMPOSITIONS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR PRODUCING AQUEOUS DISPERSIONS OF PHARMACEUTICAL COMPOSITIONS
Document Type and Number:
Japanese Patent JP2023008595
Kind Code:
A
Abstract:
To provide pharmaceutical compositions comprising an atomized hardly water soluble drug and production methods thereof, and methods for preparing pharmaceutical composition-containing aqueous dispersions with excellent stability.SOLUTION: Disclosed is a method for producing a pharmaceutical composition comprising the steps of: (a) mechanically kneading a hardly water-soluble drug, a water soluble inorganic salt and a water soluble organic solvent; and (b) removing the water soluble inorganic salt and water soluble organic solvent following the step (a), where the water soluble organic solvent satisfies the following (i) to (iii): (i) its molecular weight is 100-350; (ii) it has two or more functional groups comprising hydroxy group and/or ester group; (iii) its viscosity at 60°C is 2-150 mPa s.SELECTED DRAWING: None
Inventors:
YAMAMOTO YUICHI
KARAKIDA NAOTO
FUJINO TAKUYA
KARAKIDA NAOTO
FUJINO TAKUYA
Application Number:
JP2021112274A
Publication Date:
January 19, 2023
Filing Date:
July 06, 2021
Export Citation:
Assignee:
TOYO INK SC HOLDINGS CO LTD
International Classes:
A61K9/10; A61K31/015; A61K31/12; A61K31/167; A61K31/192; A61K31/216; A61K31/404; A61K31/405; A61K31/41; A61K31/4174; A61K31/4422; A61K31/56; A61K31/573; A61K45/00; A61K47/32