Title:
METHODS FOR TREATING MULTIPLE SCLEROSIS
Document Type and Number:
Japanese Patent JP2022168243
Kind Code:
A
Abstract:
To provide safer methods for treating patients with multiple sclerosis using fumarates taking into consideration of the possibility of acquiring progressive multifocal leukoencephalopathy (PML).SOLUTION: Provided is a method for treating a patient with multiple sclerosis, which comprises: (a) administering to the patient a fumarate, where the fumarate is a fumarate dialkyl, a fumarate monoalkyl, a combination of a fumarate dialkyl and a fumarate monoalkyl, a prodrug of a fumarate monoalkyl, deuterated form of any of the foregoing, or a pharmaceutically acceptable salt, clathrate, solvate, tautomer, stereoisomer of any of the foregoing, or a combination of any the foregoing; and (b) monitoring the patient for a sign or symptom suggestive of PML.SELECTED DRAWING: Figure 1
Inventors:
Mark Novas
Louis (Ray) Zhang
Louis (Ray) Zhang
Application Number:
JP2022145173A
Publication Date:
November 04, 2022
Filing Date:
September 13, 2022
Export Citation:
Assignee:
Biogen MA Inc.
International Classes:
A61K9/20; A61K31/225; A61K9/28; A61K9/48; A61P25/00; A61P43/00
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki