MICROBIOLOGICAL PREPARATION OF HETEROAROMATIC CARBOXYLIC ACID BY USE OF ALCALIGENES MICROORGANISM

Title:

MICROBIOLOGICAL PREPARATION OF HETEROAROMATIC CARBOXYLIC ACID BY USE OF ALCALIGENES MICROORGANISM

Document Type and Number:

Japanese Patent JP3810860

Kind Code:

B2

Abstract:

PROBLEM TO BE SOLVED: To efficiently obtain the subject compound useful as a raw material for herbicides, etc., by treating a heteroaromatic nitrile as a substrate with an Alcaligenes microorganism assimilating 2-cyanopyridine and cultured in the presence of a polybasic carboxylic acid or a hydrocarbon.
SOLUTION: This microbiological process for the preparation of a heteroaromatic carboxylic acid or one of its physiologically tolerated salts comprises adding a heteroaromatic nitrile of formula I or II (R1 and R2 are each H or a halogen; X is N or CH) (for example, 2-cyanopyridine) as a substrate to a culture medium, treating the compound of formula I or II with an Alcaligenes microorganism [for example, Alcaligenes faecalis (DSM 6335)] assimilating 2-cyanopyridine and cultured in the presence of a dicarboxylic acid, a tricarboxylic acid or a hydrocarbon before the biological conversion to convert into the corresponding carboxylic acid of formula III or IV (for example, 6-hydroxypicolinic acid) and, if suitable, further converting the obtained carboxylic acid into the corresponding physiologically tolerated salt. Thus, the heteroaromatic carboxylic acid useful as an intermediate for producing medicines, herbicides, etc., is efficiently obtained.

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Inventors:

Andreas Keener
Jean-Paul Rodui
Liner Geckler

Application Number:

JP14271996A

Publication Date:

August 16, 2006

Filing Date:

June 05, 1996

Export Citation:

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Assignee:

LONZA LIMITED

International Classes:

C12P17/10; C07D213/79; C12P17/12; C07D241/24; C12P17/14; C12R1/05; (IPC1-7): C12P17/12; C07D213/79; C07D241/24; //(C12P17/12; C12R1:05)

Domestic Patent References:

JP5115279A

Other References:

J.Chem.Soc.Perkin Trans.1,(1993),(11),p1201-1202

Attorney, Agent or Firm:

Takehiko Suzue
Sadao Muramatsu
Atsushi Tsuboi
Ryo Hashimoto
Toshio Shirane

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