To provide a high-quality microneedle device capable of being punctured with a small force into the skin without causing pain, and after punctured, smoothly injecting chemical liquids or sucking blood or body liquid.
In the structure, a plurality of needle-like projections 12 are arranged on the upper surface of a flat substrate 11 integrally with the substrate. The needle-like projections each have in the inside a fluid tube 15 vertical or substantially vertical to the substrate, and the fluid tube is formed penetrating through from a position near to the front end of the needle-like projection subtly from a boundary surface to the bottom of the substrate. The needle-like projections are each made of two upper-lower layers of different materials bordered with a boundary surface horizontal or substantially horizontal to the substrate, and a first material 14a of the front end side portion from the boundary surface is a soluble material which is soluble if it contacts the human skin and a second material 14b of the substrate side portion from the boundary surface is an insoluble material which is not soluble if it contacts the human skin. A front end 17 of each of the needle-like projections has a shape in which an inclined flat surface 70 having an inclination smaller than that of the side surface of the needle-like projection is formed.
| JP6934721 | Microneedle and its manufacturing method |
| WO/1995/033511 | METHOD AND DEVICE FOR LONG-TERM DELIVERY OF DRUGS |
| JP5879126 | Phase transition polymer microneedles |
MORI HIDEKI
| JPH11509123A | 1999-08-17 | |||
| JP2010069253A | 2010-04-02 | |||
| JP2011012050A | 2011-01-20 | |||
| JP2004524172A | 2004-08-12 | |||
| JP2004532698A | 2004-10-28 |
| WO2008020632A1 | 2008-02-21 | |||
| WO2010117602A2 | 2010-10-14 | |||
| WO2011018909A1 | 2011-02-17 |
Takakura Shigeo
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Kocho Chojiro
Naoki Kono
Katsu Sunagawa
Morisezo Iseki
Tatsushi Sato
Takashi Okada
Mihoko Horiuchi
Takenori Masanori