Title:
ULTRASMALL NANOPARTICLES AND METHODS OF MAKING AND USING THE SAME
Document Type and Number:
Japanese Patent JP2023055854
Kind Code:
A
Abstract:
To provide ultrasmall nanoparticles and methods of making and using the same.SOLUTION: An aqueous synthesis method for preparation of silica nanoparticles (SNPs) and core-shell SNPs having, for example, a size of 2 to 15 nm and narrow size-dispersion with size control below 1 nm, i.e., at the level of a single atomic layer. Different types of dyes, including near infrared (NIR) emitters, can be covalently encapsulated inside and brightness can be enhanced via addition of extra silica shells. A surface thereof may be functionalized with polyethylene glycol (PEG) groups and, optionally, specific surface ligands. This aqueous synthesis method also enables synthesis of 2 to 15 nm sized fluorescent core and core-shell aluminosilicate nanoparticles (ASNPs), which may also be surface-functionalized. Encapsulation efficiency and brightness of highly negatively charged NIR fluorophores are enhanced relative to the corresponding SNPs without aluminum.SELECTED DRAWING: None
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Inventors:
Wiesner, Ulrich, Bee
Ma, Kai
Mendoza, Curly
Ma, Kai
Mendoza, Curly
Application Number:
JP2023014350A
Publication Date:
April 18, 2023
Filing Date:
February 02, 2023
Export Citation:
Assignee:
CORNELL UNIVERSITY
International Classes:
A61K9/16; A61K47/02; A61K47/10; A61K47/24; A61K49/00
Attorney, Agent or Firm:
Patent Attorney Corporation Minori Patent Office
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