Title:
MODULATOR OF ATP-BINDING CASSETTE TRANSPORTER
Document Type and Number:
Japanese Patent JP2015091875
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide modulators of ATP-Binding Cassette transporters.SOLUTION: The present invention relates to the modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators (I) or a pharmaceutically acceptable salt thereof. Ht is a 5-membered heteroaromatic ring containing 1-4 heteroatoms, and the ring is optionally condensed into a carbocyclic ring, a heterocyclic ring, an aromatic ring or a non-aromatic ring; ring A is 3-7 membered monocyclic ring having 0-3 heteroatoms; and ring B is optionally condensed into 5-6 membered carbocyclic or heterocyclic, aromatic or non-aromatic ring.
Inventors:
HADIDA RUAH SARAH S
GROOTENHUIS PETER D J
MILLER MARK T
MATTHEW HAMILTON
GROOTENHUIS PETER D J
MILLER MARK T
MATTHEW HAMILTON
Application Number:
JP2015019897A
Publication Date:
May 14, 2015
Filing Date:
February 04, 2015
Export Citation:
Assignee:
VERTEX PHARMA
International Classes:
C07D233/88; A61K31/4178; A61K31/421; A61K31/4245; A61K31/426; A61K31/427; A61K31/428; A61K31/433; A61K31/438; A61K31/443; A61K31/4439; A61K31/454; A61K31/496; A61K31/497; A61K31/5377; A61K45/00; A61P1/12; A61P3/00; A61P3/06; A61P3/10; A61P5/00; A61P5/10; A61P5/14; A61P5/16; A61P5/48; A61P7/02; A61P7/04; A61P7/10; A61P11/00; A61P13/02; A61P17/00; A61P19/08; A61P21/00; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P35/00; A61P37/06; A61P43/00; C07D231/40; C07D263/48; C07D271/113; C07D277/46; C07D277/54; C07D277/82; C07D285/135; C07D405/12; C07D407/12; C07D409/12; C07D409/14; C07D413/12; C07D417/04; C07D417/06; C07D417/12; C07D417/14; C07D491/113; C07D493/10; G01N33/15; G01N33/50; C07D271/10; C07D285/12
Domestic Patent References:
| JP2004501146A | 2004-01-15 | |||
| JP2003514816A | 2003-04-22 |
Foreign References:
| WO2001046165A2 | 2001-06-28 |
Attorney, Agent or Firm:
Takeshi Oshio