Title:
一置換又は多置換の油水両親媒性ヒポクレリン誘導体及びその使用
Document Type and Number:
Japanese Patent JP7479997
Kind Code:
B2
Abstract:
The invention discloses a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, and a preparation method and application thereof. The amphiphilic hypocrellin derivative substituted by a group containing PEG, a quaternary ammonium salt or the like prepared according to the invention has an obvious red shift in its absorption spectrum and a significantly enhanced molar extinction coefficient, compared with the parent hypocrellin, can efficiently produce singlet state oxygen and other reactive oxygen species under photosensitive conditions; has different amphiphilicities and increased biocompatibility with cells or tissues by regulating its hydrophilicity and hydrophobicity; can meet the requirements of different clinical drugs, and solves the requirements of different drug delivery methods for different drug hydrophilicity and lipophilicity. Under identical conditions, the amphiphilic hypocrellin derivative photosensitizer according to the invention has higher ability to photodynamically inactivate tumor cells than the first and second generation commercial photosensitizers.
Inventors:
Wang Pengfei
Woo Jia-seon
Liu Weimin
Goo In
Gua Ji Chao
Jon Shuri
Zhang Hongyen
Woo Jia-seon
Liu Weimin
Goo In
Gua Ji Chao
Jon Shuri
Zhang Hongyen
Application Number:
JP2020143916A
Publication Date:
May 09, 2024
Filing Date:
August 27, 2020
Export Citation:
Assignee:
Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences
International Classes:
C07C251/18; A61K31/136; A61K31/14; A61K31/16; A61K31/25; A61K31/255; A61K31/4402; A61K31/4425; A61K31/4468; A61K31/498; A61K31/4995; A61K31/5415; A61K35/74; A61K41/00; A61P9/00; A61P17/00; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; C07C211/63; C07C225/22; C07C229/08; C07C237/08; C07C239/14; C07C239/16; C07C243/22; C07C251/86; C07C309/69; C07C321/14; C07D211/58; C07D213/36; C07D241/38; C07D279/14; C07D487/08; C07D513/04; C07D513/16
Domestic Patent References:
| JP2005518329A | ||||
| JP2009505968A |
Foreign References:
| CN103570567A |
Other References:
J.Phys.Chem.B、(2008)、Vol.112、No.32、pp.9959-9965
J.Med.Chem.、(2012)、55、pp.1910-1919
Photochemistry and Photobiology、(2010)、86、pp.667-672
J.Med.Chem.、(2012)、55、pp.1910-1919
Photochemistry and Photobiology、(2010)、86、pp.667-672
Attorney, Agent or Firm:
Patent Attorney Corporation ATEN