Title:
MURAMYLDIPEPTIDE DERIVATIVE
Document Type and Number:
Japanese Patent JPS5618996
Kind Code:
A
Abstract:
NEW MATERIAL:A muramyldipeptide derivative of formula I [X is residue of amino acid such as L-alanine, L-serine, etc.; Y is -NH-A or group of formula II [R1 is H, lower alkyl, carboxamide, etc., n is 1W6; A is 7W30C (branched) aliphatic hydrocarbon residue]; Acyl is acyl].
EXAMPLE: Nα-(N-Acetylmuramyl-L-alany-D-isoglutaminyl)-N-octanoyl-L-lysine.
USE: Adjuvant activating agent; preventive and remedy for microbial infection.
PROCESS: For example, a compound of formula III (e.g. N-acetylmuramyl-L-alanyl- D-isoglutamine) and a compound of formula H-Y are dissolved or disperesed in a solvent such as DMF, and reacted with N-hydroxysuccinimide, etc. and dicyclohexyl-carbodiimide, etc. at room temp. to 60°C for several hours to several days.
Inventors:
SHIBA TETSUO
KOTANI SHIYOUZOU
YAMAMURA YUUICHI
NAGASE MINORU
OGAWA HIDEMASA
KOTANI SHIYOUZOU
YAMAMURA YUUICHI
NAGASE MINORU
OGAWA HIDEMASA
Application Number:
JP7831779A
Publication Date:
February 23, 1981
Filing Date:
June 21, 1979
Export Citation:
Assignee:
DAIICHI SEIYAKU CO
International Classes:
A61K31/70; A61K38/00; A61K39/39; A61P31/04; C07H15/04; C07K9/00; (IPC1-7): A61K31/70; A61K39/39; C07H13/12
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