Title:
NK1アンタゴニスト
Document Type and Number:
Japanese Patent JP4459621
Kind Code:
B2
Abstract:
A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceuticals compositions. Methods of treatment and combinations with other agents are also disclosed.
Inventors:
Richard, Gregory A.
Pariwar Sunil
See, Nen-Yang
Xiao, Dong
Tsui, Hong-Chun
Shah, Sapna
Wan, Chen
Wrobleski, Michelle El.
Pariwar Sunil
See, Nen-Yang
Xiao, Dong
Tsui, Hong-Chun
Shah, Sapna
Wan, Chen
Wrobleski, Michelle El.
Application Number:
JP2003544010A
Publication Date:
April 28, 2010
Filing Date:
November 12, 2002
Export Citation:
Assignee:
Schering Corporation
International Classes:
C07D207/24; C07D211/76; A61K31/4015; A61K31/4439; A61K31/451; A61K31/454; A61K45/00; A61P1/00; A61P1/08; A61P3/04; A61P3/10; A61P9/10; A61P11/00; A61P13/00; A61P15/00; A61P17/00; A61P25/00; A61P25/04; A61P25/06; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/32; A61P27/02; A61P29/00; C07D207/22; C07D207/26; C07D207/273; C07D207/277; C07D207/36; C07D207/38; C07D211/86; C07D401/04; C07D403/04
Domestic Patent References:
| JP8502510A |
Foreign References:
| WO2001044200A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita
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