PURPOSE: To produce the title compound useful as a raw material useful for a raw material for isocyanate in high yield, industrially and advantageously in esterifying an amino acid hydrochloride with an amino-alcohol hydrochloride by carrying out the esterification reaction while introducing a hydrogen chloride gas.
CONSTITUTION: An amino acid hydrochloride (e.g. hydrochloride of amino acid such as glycine, 3-aminopropionic acid, pyrrolidone or caprolactam) is reacted with an amino-alcohol hydrochloride (e.g. hyrochloride of ethanolamine or 1- amino-2-propanol) under 50-400mmHg, preferably 60-310mmHg at about 50-160°C for about 3-20 hours while introducing preferably 50-100ml (at normal temperature under normal pressure) hydrogen chloride gas per mol amino acid hydrochloride per minute to give an amino acid alkyl ester. The objective compound is obtained in high yield by this method.
YUMINO YASUHISA
HARADA KENJI
KUBOTA YOSHIYASU
