Title:
白金化合物のナノ粒子配合物
Document Type and Number:
Japanese Patent JP2007530497
Kind Code:
A
Abstract:
Solid Lipid Nanoparticles of platinum compounds, particularly of antitumor platinum complexes are disclosed. The Nanoparticles of the invention are obtained by a process comprising: a) preparing a first microemulsion by mixing a molten lipid, a surfactant, and optionally a co-surfactant and the platinum compound acqueous solution; b) preparing a solution by mixing a surfactant and optionally a co-surfactant in water, heating to complete solution, preferably at the same melting temperature of the lipid used in a) and adding a co-surfactant; c) dispersing the microemulsion obtained in a) into the solution obtained in b) obtaining a multiple microemulsion c); d) dispersing the microemulsion obtained in c) in aqueous medium at a temperature ranging from 0.5° C. to 4° C. obtaining a dispersion of solid lipid microspheres; e) washing with aqueous medium through ultrafiltration the obtained lipid microspheres obtained in d) and lyophilizing, optionally in the presence of a bulking agent and of a cryoprotecting agent.
Inventors:
Gasco, Maria Rosa
Gasco, Paolo
Bern knowledge, Alberto
Gasco, Paolo
Bern knowledge, Alberto
Application Number:
JP2007504372A
Publication Date:
November 01, 2007
Filing Date:
March 24, 2005
Export Citation:
Assignee:
CELL THERAPEUTICS EUROPE S.r.l.
NANOVECTOR s.R.L.
NANOVECTOR s.R.L.
International Classes:
A61K31/282; A61K9/19; A61K9/51; A61P35/00; B82B1/00; B82B3/00; B01J13/00
Domestic Patent References:
| JP2002512589A | 2002-04-23 |
Foreign References:
| US5250236A | 1993-10-05 | |||
| US6596889B1 | 2003-07-22 |
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda