Title:
ナチュラルキラー細胞の増殖剤及び増殖方法
Document Type and Number:
Japanese Patent JP3970916
Kind Code:
B2
Abstract:
A method for screening for a substance having an action of proliferating natural killer (NK) cells in a living body of an animal (except for human), which comprises:
administering a test substance to the animal every day for 7 days,
administering polyinosinic-polycytidylic acid single dose to the animal at 3 days before the completion of the administration of the test substance, for enhancing the action of the test substance of proliferating NK cells,
detecting induction of the proliferation of NK cells in the animal, and
selecting test substances capable of proliferating NK cells.
Inventors:
Tetsuya Kuhara
Taketo Ito
Taketo Ito
Application Number:
JP2006535800A
Publication Date:
September 05, 2007
Filing Date:
September 07, 2005
Export Citation:
Assignee:
Morinaga Milk Industry Co., Ltd.
International Classes:
A61K38/16; A61K31/7088; A61P35/00; A61P43/00; C12N5/07; C12N5/0783; C12N5/09; C12Q1/04; G01N33/15; G01N33/50
Other References:
津田 洋幸ら,ラクトフェリンによる発がん予防とその機序の解析,FFI Journal,2002年,No.200,p.27-35
Wen-Ping Wang et al.,Activation of Intestinal Mucosal Immunity in Tumor-bearing Mice by Lactoferrin,Jpn.J.Cancer Res.,2000年,Vol.91,p.1022-1027
Hiroyuki Tsuda et al.,Cancer prevention by bovine lactoferrin and underlying mechanisms- a review of experimental and clinical studies,Biochem. Cell Biol.,2002年,Vol.80,p.131-136
Marion T. Kasaian et al.,Cyclosporin A Inhibition of Interleukin 2 Gene Expression, but not Natural Killer Cell Proliferation, after Interferon Induction in Vivo,J. Exp. Med.,1990年,Vol.171,p.745-762
Carlo Riccardi et al.,Generation of Mouse Natural Killer(NK) Cell Activity: Effect of Interleukin-2(IL-2) and Interferon (IFN) on the in vivo Development of Natural Killer Cells from Bone Marrow (BM) Progenitor Cells,Int.J.Cancer,1986年,Vol.38,p.553-562
Wen-Ping Wang et al.,Activation of Intestinal Mucosal Immunity in Tumor-bearing Mice by Lactoferrin,Jpn.J.Cancer Res.,2000年,Vol.91,p.1022-1027
Hiroyuki Tsuda et al.,Cancer prevention by bovine lactoferrin and underlying mechanisms- a review of experimental and clinical studies,Biochem. Cell Biol.,2002年,Vol.80,p.131-136
Marion T. Kasaian et al.,Cyclosporin A Inhibition of Interleukin 2 Gene Expression, but not Natural Killer Cell Proliferation, after Interferon Induction in Vivo,J. Exp. Med.,1990年,Vol.171,p.745-762
Carlo Riccardi et al.,Generation of Mouse Natural Killer(NK) Cell Activity: Effect of Interleukin-2(IL-2) and Interferon (IFN) on the in vivo Development of Natural Killer Cells from Bone Marrow (BM) Progenitor Cells,Int.J.Cancer,1986年,Vol.38,p.553-562
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi
Hidemi Matsukura
Tsutomu Toyama
Hidemi Matsukura
Tsutomu Toyama
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