ネオセントロメアに基づくミニ染色体又は人工染色体

Title:

ネオセントロメアに基づくミニ染色体又は人工染色体

Document Type and Number:

Japanese Patent JP4150588

Kind Code:

B2

Abstract:

The present invention is directed generally to a defined or isolated nucleic acid molecule encompassing a neocentreomere or a functional derivative thereof or a latent, synthetic or hybrid form thereof and its use inter alia in developing a range of eukaryotic mini-chromosomes and artificial chromosomes including mammalian (e.g. human) and non-mammalian mini-chromosomes and artificial chromosomes. The present invention further provides a telomere-associated chromosome truncation (TACT) approach to develop mini-chromosomes, but is not limited to this approach. It is directed to any truncation approach that produces a neocentromere-containing mini-chromosome, or any transfection approach using cloned or pre-fabricated DNA that provides neocentromere function in the construction of artificial chromosome. Such mini-chromosomes and artificial chromosomes are useful in a range of genetic therapies.

Inventors:

Chu, Kong-Hong, Andy
Wong, Lee, Hua
Safari, richard, eric

Application Number:

JP2002552165A

Publication Date:

September 17, 2008

Filing Date:

December 20, 2001

Export Citation:

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