Title:
ニューロンの発生、再生および保護
Document Type and Number:
Japanese Patent JP5797638
Kind Code:
B2
Abstract:
The invention demonstrates that, contrary to apoptotic rabies virus G proteins, certain non-apoptotic rabies virus G proteins, such as the G protein of the CVS-NIV strain, have a neurite outgrowth promoting effect. The invention further demonstrates that this neurite outgrowth promoting effect is due to the cytoplasmic tail of said non-apoptotic rabies virus G proteins, more particularly to their PDZ-BS, which shows a single-point mutation compared to the one of apoptotic rabies virus G proteins. The invention provides means for inducing and/or stimulating neurite outgrowth, which are useful in inducing neuron differentiation, for example for the treatment of a neoplasm of the nervous system, as well as in regenerating impaired neurons, for example for the treatment of a neurodegenerative disease, disorder or condition or in the treatment of a microbial infection, or in protecting neurons from neurotoxic agents or oxidative stress.
Inventors:
Pleaux, Christoph
Lafon, Monik
Schnell, Matthias Johannes
Lafon, Monik
Schnell, Matthias Johannes
Application Number:
JP2012504095A
Publication Date:
October 21, 2015
Filing Date:
April 02, 2010
Export Citation:
Assignee:
INSTITUT PASTEUR
Thomas Jefferson University
Thomas Jefferson University
International Classes:
A61K38/00; A61K31/7088; A61K48/00; A61P25/00; A61P25/16; A61P25/18; A61P25/28; A61P35/00; A61K35/13
Domestic Patent References:
| JP2006502240A | ||||
| JP2004517057A |
Foreign References:
| EP0094887A1 | ||||
| WO2008138649A1 |
Attorney, Agent or Firm:
Kurata Masatoshi
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Katsu Sunagawa
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Katsu Sunagawa
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